The oxidative phosphorylation system in mammalian mitochondria
S Papa, PL Martino, G Capitanio, A Gaballo… - Advances in …, 2012 - Springer
S Papa, PL Martino, G Capitanio, A Gaballo, D De Rasmo, A Signorile, V Petruzzella
Advances in Mitochondrial Medicine, 2012•SpringerThe chapter provides a review of the state of art of the oxidative phosphorylation system in
mammalian mitochondria. The sections of the paper deal with:(i) the respiratory chain as a
whole: redox centers of the chain and protonic coupling in oxidative phosphorylation (ii)
atomic structure and functional mechanism of protonmotive complexes I, III, IV and V of the
oxidative phosphorylation system (iii) biogenesis of oxidative phosphorylation complexes:
mitochondrial import of nuclear encoded subunits, assembly of oxidative phosphorylation …
mammalian mitochondria. The sections of the paper deal with:(i) the respiratory chain as a
whole: redox centers of the chain and protonic coupling in oxidative phosphorylation (ii)
atomic structure and functional mechanism of protonmotive complexes I, III, IV and V of the
oxidative phosphorylation system (iii) biogenesis of oxidative phosphorylation complexes:
mitochondrial import of nuclear encoded subunits, assembly of oxidative phosphorylation …
Abstract
The chapter provides a review of the state of art of the oxidative phosphorylation system in mammalian mitochondria. The sections of the paper deal with:
- (i) the respiratory chain as a whole: redox centers of the chain and protonic coupling in oxidative phosphorylation
- (ii) atomic structure and functional mechanism of protonmotive complexes I, III, IV and V of the oxidative phosphorylation system
- (iii) biogenesis of oxidative phosphorylation complexes: mitochondrial import of nuclear encoded subunits, assembly of oxidative phosphorylation complexes, transcriptional factors controlling biogenesis of the complexes.
This advanced knowledge of the structure, functional mechanism and biogenesis of the oxidative phosphorylation system provides a background to understand the pathological impact of genetic and acquired dysfunctions of mitochondrial oxidative phosphorylation.
Springer
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