[HTML][HTML] The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading
BM Gardner, DT Castanzo, S Chowdhury… - Nature …, 2018 - nature.com
Pex1 and Pex6 form a heterohexameric motor essential for peroxisome biogenesis and
function, and mutations in these AAA-ATPases cause most peroxisome-biogenesis
disorders in humans. The tail-anchored protein Pex15 recruits Pex1/Pex6 to the peroxisomal
membrane, where it performs an unknown function required for matrix-protein import. Here
we determine that Pex1/Pex6 from S. cerevisiae is a protein translocase that unfolds Pex15
in a pore-loop-dependent and ATP-hydrolysis-dependent manner. Our structural studies of …
function, and mutations in these AAA-ATPases cause most peroxisome-biogenesis
disorders in humans. The tail-anchored protein Pex15 recruits Pex1/Pex6 to the peroxisomal
membrane, where it performs an unknown function required for matrix-protein import. Here
we determine that Pex1/Pex6 from S. cerevisiae is a protein translocase that unfolds Pex15
in a pore-loop-dependent and ATP-hydrolysis-dependent manner. Our structural studies of …
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