The possible ameliorative effect of simvastatin versus sulfasalazine on acetic acid induced ulcerative colitis in adult rats

NA Soliman, WA Keshk, FH Rizk, MA Ibrahim - Chemico-biological …, 2019 - Elsevier
Objective Inflammatory bowel diseases (IBD) are chronic and recurrent disorders of the
gastrointestinal tract with unknown etiology and have two major forms, ulcerative colitis (UC)
and Crohn diseases. In view of the adverse effects and incomplete efficacy of currently
administered drugs, it is essential to investigate new and harmless drugs with more
desirable beneficial effects. Statins have many additional pleiotropic effects other than their
lipid-lowering effect. This study aims to investigate the role of simvastatin (SIM) at different …
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