The quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls
E Cifuentes-Pagano, DN Meijles… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Numerous studies in animal models and human subjects corroborate that
elevated levels of reactive oxygen species (ROS) play a pivotal role in the progression of
multiple diseases. As a major source of ROS in many organ systems, the NADPH oxidase
(Nox) has become a prime target for therapeutic development. Recent Advances: In recent
years, intense efforts have been dedicated to the development of pan-and isoform-specific
Nox inhibitors as opposed to antioxidants that proved ineffective in clinical trials. Over the …
elevated levels of reactive oxygen species (ROS) play a pivotal role in the progression of
multiple diseases. As a major source of ROS in many organ systems, the NADPH oxidase
(Nox) has become a prime target for therapeutic development. Recent Advances: In recent
years, intense efforts have been dedicated to the development of pan-and isoform-specific
Nox inhibitors as opposed to antioxidants that proved ineffective in clinical trials. Over the …
The Quest for Selective Nox Inhibitors and Therapeutics: Challenges, Triumphs and Pitfalls
N MeijlesDaniel, J PaganoPatrick - Antioxidants & Redox …, 2014 - liebertpub.com
Significance: Numerous studies in animal models and human subjects corroborate that
elevated levels of reactive oxygen species (ROS) play a pivotal role in the progression of
multiple diseases. As a major source of ROS in many organ systems, the NADPH oxidase
(Nox) has become a prime target for therapeutic development. Recent Advances: In recent
years, intense efforts have been dedicated to the development of pan-and isoform-specific
Nox inhibitors as opposed to antioxidants that proved ineffective in clinical trials. Over the …
elevated levels of reactive oxygen species (ROS) play a pivotal role in the progression of
multiple diseases. As a major source of ROS in many organ systems, the NADPH oxidase
(Nox) has become a prime target for therapeutic development. Recent Advances: In recent
years, intense efforts have been dedicated to the development of pan-and isoform-specific
Nox inhibitors as opposed to antioxidants that proved ineffective in clinical trials. Over the …
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