▪ Abstract Nitric oxide (NO) is a small, diffusible, lipophilic free radical gas that mediates
significant and diverse signaling functions in nearly every organ system in the body. The
endothelial isoform of nitric oxide synthase (eNOS) is a key source of NO found in the
cardiovascular system. This review summarizes the pharmacology of NO and the cellular
regulation of endothelial NOS (eNOS). The molecular intricacies of the chemistry of NO and
the enzymology of NOSs are discussed, followed by a review of the biological activities of …