According to recent studies [1, 2], nutrition is believed to play a role in the pathogenesis of adverse pregnancy outcomes, including preterm birth and subsequent neonatal sepsis. Trace elements such as copper (Cu) and zinc (Zn) are essential for a pregnancy with good outcomes for both mother and infant. As a result, deficiency of these elements plays an important role in neonatal complications such as neonatal sepsis [3]. In other words, pregnant women, especially in developing countries, are considered a highrisk group for trace elements deficiency, especially Zn and Cu [4]. Previous studies have investigated the association between nutritional deficiencies with the risk of increased neonatal sepsis, but few studies have examined the status of these elements during neonatal sepsis and its association with disease severity [3, 4]. Therefore, we conducted a pilot study on 40 term neonates with neonatal sepsis at Bandar Abbas City, Iran in 2019 that were diagnosed according to clinical and laboratory criteria, and serum levels of Cu and Zn at day 1 and day 5 were compared. In this study, 27 male and 13 female infants were enrolled. The mean age of neonates was 8.9±8.44 days and the mean gestational age was 38.72±1.07 weeks. As shown in Figure 1, Zn and Cu levels were 93.05±41.42 and 70.15±26.15 mcg/dL on day 1, respectively, while on day 5, Zn and Cu levels were 98.38±37 and 76.5±32.04 mcg/dL, respectively. According to the results of our study, Cu levels in neonates with neonatal sepsis were higher than the normal range (20-70 mcg/dL), which increased with increasing duration of infection, although this increase was not significant (P˃ 0.05). The results also showed that Zn levels in neonates, although within the normal range (80-120 mcg/dL)[5] and increased after 5 days, not statistically significant (P˃ 0.05). Neonatal Cu and Zn levels have a direct relationship with maternal serum levels during pregnancy [6]. While it is difficult to assess the prevalence of Zn deficiency, numerous studies have suggested the possibility of mild to moderate Zn deficiency widely in pregnant women. The prevalence of Zn deficiency in developing countries is probably similar to that of iron deficiency [7]. Caulfield et al reported that 82% of pregnant women worldwide are likely to have inadequate Zn intake [8]. Severe Zn deficiency, although uncommon, is associated with spontaneous abortion and congenital malformations. While milder forms of deficiency are associated with low birth weight, intrauterine growth restriction and preterm delivery. In addition, mild Zn deficiency may be associated with complications of childbirth,