The revitalized tau hypothesis on Alzheimer's disease
RB Maccioni, G Farías, I Morales, L Navarrete - Archives of medical …, 2010 - Elsevier
Many hypotheses have been raised regarding the pathophysiology of Alzheimer's disease
(AD). Because amyloid beta peptide (Aβ) deposition in senile plaques appears as a late,
nonspecific event, recent evidence points to tau phosphorylation and aggregation as the
final common pathway in this multifactorial disease. Current approaches that provide
evidence in favor of neuroimmunomodulation in AD and the roles of tau pathological
modifications and aggregation into oligomers and filamentous forms are presented. We …
(AD). Because amyloid beta peptide (Aβ) deposition in senile plaques appears as a late,
nonspecific event, recent evidence points to tau phosphorylation and aggregation as the
final common pathway in this multifactorial disease. Current approaches that provide
evidence in favor of neuroimmunomodulation in AD and the roles of tau pathological
modifications and aggregation into oligomers and filamentous forms are presented. We …
The Revitalized Tau Hypothesison Alzheimer's Disease
R Maccioni Baraona, G Farías, I Morales, L Navarrete - 2010 - repositorio.uchile.cl
Many hypotheses have been raised regarding the pathophysiology of Alzheimer's disease
(AD). Because amyloid beta peptide (Ab) deposition in senile plaques appears as a late,
nonspecific event, recent evidence points to tau phosphorylation and aggregation as the
final common pathway in this multifactorial disease. Current approaches that provide
evidence in favor of neuroimmunomodulation in AD and the roles of tau pathological
modifications and aggregation into oligomers and filamentous forms are presented. We …
(AD). Because amyloid beta peptide (Ab) deposition in senile plaques appears as a late,
nonspecific event, recent evidence points to tau phosphorylation and aggregation as the
final common pathway in this multifactorial disease. Current approaches that provide
evidence in favor of neuroimmunomodulation in AD and the roles of tau pathological
modifications and aggregation into oligomers and filamentous forms are presented. We …