The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein
DA Canton, MEK Olsten, H Niederstrasser… - Journal of Biological …, 2006 - ASBMB
CKIP-1 is a pleckstrin homology domain-containing protein that induces alterations of the
actin cytoskeleton and cell morphology when expressed in human osteosarcoma cells. CKIP-
1 interacts with the heterodimeric actin-capping protein in cells, so we postulated that this
interaction was responsible for the observed cytoskeletal and morphological effects of CKIP-
1. To test this postulate, we used peptide" walking arrays" and alignments of CKIP-1 with
CARMIL, another CP-binding protein, to identify Arg-155 and Arg-157 of CKIP-1 as residues …
actin cytoskeleton and cell morphology when expressed in human osteosarcoma cells. CKIP-
1 interacts with the heterodimeric actin-capping protein in cells, so we postulated that this
interaction was responsible for the observed cytoskeletal and morphological effects of CKIP-
1. To test this postulate, we used peptide" walking arrays" and alignments of CKIP-1 with
CARMIL, another CP-binding protein, to identify Arg-155 and Arg-157 of CKIP-1 as residues …
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