The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway
Fanconi anemia (FA) is a hereditary disorder characterized by a deficiency in the repair of
DNA interstrand crosslinks and the response to replication stress. Endogenous DNA
damage, most likely caused by aldehydes, severely affects hematopoietic stem cells in FA,
resulting in progressive bone marrow failure and the development of leukemia. Recent
studies revealed that expression levels of SLFN11 affect the replication stress response and
are a strong determinant in cell killing by DNA-damaging cancer chemotherapy. Because …
DNA interstrand crosslinks and the response to replication stress. Endogenous DNA
damage, most likely caused by aldehydes, severely affects hematopoietic stem cells in FA,
resulting in progressive bone marrow failure and the development of leukemia. Recent
studies revealed that expression levels of SLFN11 affect the replication stress response and
are a strong determinant in cell killing by DNA-damaging cancer chemotherapy. Because …
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