Background

This study aims to investigate predictive factors of identification of the need of patients for extracorporeal membrane oxygenation support during lung transplantation.

Methods

A total of 63 patients (49 males, 14 females, mean age: 44.9±14.4 years; range, 14 to 64 years) who underwent lung transplantation in our institution between December 2016 and December 2019 were retrospectively analyzed. Demographic characteristics and perioperative clinical data of patients were recorded. After induction and pulmonary artery catheterization, cardiac output, mean pulmonary artery pressure, pulmonary capillary wedge pressure, cardiac index, pulmonary vascular resistance, systemic vascular resistance, and right atrial pressure were measured using the thermodilution technique.

Results

Thirty-three of the patients received extracorporeal membrane oxygenation support during surgery. The right atrial pressure (p< 0.001), pulmonary capillary wedge pressure (p< 0.002), mean pulmonary artery pressure (p< 0.001), and pulmonary vascular resistance (p< 0.001) were statistically significantly higher in the patients who required extracorporeal membrane oxygenation support intraoperatively. The systemic vascular resistance (p< 0.032) was statistically significantly lower in the patients who required extracorporeal membrane oxygenation support intraoperatively. A mean pulmonary artery pressure of> 39 mmHg (p< 0.02) and a right atrial pressure of> 12 mmHg (p< 0.047) were independent risk factors for ECMO support intraoperatively during lung transplantation.

Conclusion

Predicting the need of intraoperative extracorporeal membrane oxygenation support is of utmost importance in timing the need for mechanical support, protecting the new graft from high mechanical ventilator pressures, and adequately maintaining hemodynamic stability.