Objective Earlier studies suggest that high-calorie diet is an important risk factor for neuronal
damage resulting from oxidative stress of lipid metabolism. In our experimental study of rats
under high-fat diet, oxidative stress markers and axonal degeneration parameters were
used to observe the sciatic nerve neuropathy. The aim of this study is to evaluate the
pathophysiology of neuropathy induced by high-fat diet. Methods A total of 14 male rats
(Wistar albino) were randomly divided into two experimental groups as follows; control …