The role of radiation therapy and margin width in localized soft‐tissue sarcoma: Analysis from the US Sarcoma Collaborative
NP Gannon, DM King, CG Ethun… - Journal of surgical …, 2019 - Wiley Online Library
Journal of surgical oncology, 2019•Wiley Online Library
Abstract Background and Objectives Soft‐tissue sarcomas (STSs) are often treated with
resection and radiation (RT)±chemotherapy. The role of RT in decreasing resection width to
achieve local control is unclear. We evaluated RT on margin width to achieve local control
and local recurrence (LR). Methods From 2000 to 2016, 514 patients with localized STS
were identified from the US Sarcoma Collaborative database. Patients were stratified by a
margin and local control was compared amongst treatment groups. Results LR was 9% with …
resection and radiation (RT)±chemotherapy. The role of RT in decreasing resection width to
achieve local control is unclear. We evaluated RT on margin width to achieve local control
and local recurrence (LR). Methods From 2000 to 2016, 514 patients with localized STS
were identified from the US Sarcoma Collaborative database. Patients were stratified by a
margin and local control was compared amongst treatment groups. Results LR was 9% with …
Background and Objectives
Soft‐tissue sarcomas (STSs) are often treated with resection and radiation (RT)±chemotherapy. The role of RT in decreasing resection width to achieve local control is unclear. We evaluated RT on margin width to achieve local control and local recurrence (LR).
Methods
From 2000 to 2016, 514 patients with localized STS were identified from the US Sarcoma Collaborative database. Patients were stratified by a margin and local control was compared amongst treatment groups.
Results
LR was 9% with positive, 4.2% with ≤1 mm, and 9.3% with >1 mm margins (P = .315). In the ≤1 mm group, LR was 5.7% without RT, 0% with preoperative RT, and 0% with postoperative RT (P < .0001). In the >1 mm group, LR was 10.2%, 0%, and 3.7% in the no preoperative and postoperative RT groups, respectively (P = .005). RT did not influence LR in patients with positive margins. In stage I‐III and II‐III patients, local recurrence‐free survival was higher following RT (P = .008 and P = .05, respectively).
Conclusions
RT may play a larger role in minimizing LR than margin status. In patients with positive margins, RT may decrease LR to similar rates as a negative margin without RT and may be considered to decrease the risk of LR with anticipated close/positive margins.
Wiley Online Library以上显示的是最相近的搜索结果。 查看全部搜索结果