The role of stimulated lipid peroxidation and impaired calcium sequestration in the enhancement of cocaine induced hepatotoxicity by ethanol
S Öztezcan, S Doğru-Abbasoğlu… - Drug and alcohol …, 2000 - Elsevier
The purpose of this study was to investigate possible mechanism of cocaine-induced
hepatotoxicity and its potentiation by ethanol in mice. Ethanol (2 g/kg) and/or cocaine (25
mg/kg) injections were given as binge model (five injections in 3 days). Cocaine
administration with or without ethanol caused an increase in lipid peroxidation in liver
homogenate and its subcellular fractions. The greatest increases were observed in
mitochondrial fraction following cocaine plus ethanol treatment. Also, glutathione (GSH) …
hepatotoxicity and its potentiation by ethanol in mice. Ethanol (2 g/kg) and/or cocaine (25
mg/kg) injections were given as binge model (five injections in 3 days). Cocaine
administration with or without ethanol caused an increase in lipid peroxidation in liver
homogenate and its subcellular fractions. The greatest increases were observed in
mitochondrial fraction following cocaine plus ethanol treatment. Also, glutathione (GSH) …