The aim of this study is to evaluate the impact of technological innovation capabilities on innovation performance in Knowledge-Based Firms. Present study is an applied research in terms of purpose and in terms of data collecting way it is considered as a descriptive survey. The population in this study was Knowledge-Based Firms in Science and Technology Park of Tehran University and the sample size was 126 companies that to obtain this sample size random sampling method is used. The data collection tool in this study was a standard questionnaire and for reliability Cronbach's alpha coefficient was used. Structural equations modeling was used for examining of considered model. Finding in this paper show strategy planning, R&D, resource allocation, Marketing and learning capabilities can significantly improve the innovation. R&D and resource allocation capabilities can also significantly improve new product introduction. While Manufacturing and organizing capability is not affect significantly on innovation performance in Knowledge-Based Firms in Science and Technology Park of Tehran University.