The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses
AG Matthews, EK Hoffman, N Zezza, S Stiffler… - Journal of Studies on …, 2007 - jsad.com
Objective: The genes encoding the γ-aminobutyric acidA (GABAA) receptor have been the
focus of several recent studies investigating the genetic etiology of alcohol dependence.
Analyses of multilex families found a particular gene, GABRA2, to be highly associated with
alcohol dependence, using within-family association tests and other methods. Results were
confirmed in three case-control studies. The objective of this study was to investigate the
GABRA2 gene in another collection of multiplex families. Method: Analyses were based on …
focus of several recent studies investigating the genetic etiology of alcohol dependence.
Analyses of multilex families found a particular gene, GABRA2, to be highly associated with
alcohol dependence, using within-family association tests and other methods. Results were
confirmed in three case-control studies. The objective of this study was to investigate the
GABRA2 gene in another collection of multiplex families. Method: Analyses were based on …
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