The simple synthesis of quinazoline-2, 4-dione derivatives using Boc strategy
XQ Li - Chinese Chemical Letters, 2009 - Elsevier
Chinese Chemical Letters, 2009•Elsevier
Quinazolinediones are particularly attractive pharmacophores because of their wide range
of bioactivities. A convenient synthetic pathway to three-substituted quinazoline-2, 4-dione
derivatives was developed from substituted anthranilamide via carbonylation with Boc
anhydride and then cyclization in the presence of the base sodium methoxide. Good to
excellent yields have been achieved.
of bioactivities. A convenient synthetic pathway to three-substituted quinazoline-2, 4-dione
derivatives was developed from substituted anthranilamide via carbonylation with Boc
anhydride and then cyclization in the presence of the base sodium methoxide. Good to
excellent yields have been achieved.
Quinazolinediones are particularly attractive pharmacophores because of their wide range of bioactivities. A convenient synthetic pathway to three-substituted quinazoline-2,4-dione derivatives was developed from substituted anthranilamide via carbonylation with Boc anhydride and then cyclization in the presence of the base sodium methoxide. Good to excellent yields have been achieved.
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