This paper focuses on the analysis on income inequality in Italy at the municipal level of the areas defined by the National Strategy for Inner Areas. We discuss an analysis of the economic and spatial dynamics of the phenomenon through the construction of the Gini’s coefficient and the estimation of the regression model for the evaluation of the determinants of inequality. We highlight the influence of the spatial dimension on income inequality in Italy. Inequality appears to be greater in densely populated urban centers with a strong incidence of tertiary activities and young population. Conversely, in the inner areas, the distribution of income is more balanced due probably to the weakness of the social and economic structure that determines low levels of income and job opportunities mainly in the agricultural sector.