… for varied acyl modifications may thus underlie the distinct roles of the different sirtuins … the
structure, chemistry, and substrate specificity of sirtuins with a focus on how different sirtuins …

… rest of the family, these … sirtuins have been reported, which expands the potential cellular
roles of this class of enzymes. Currently, sirtuins are investigated as therapeutic targets for the …

… Recently, there has been much interest in characterizing small molecules that modify the
ability of sirtuins to deacetylate substrate proteins. In addition to nicotinamide, several specific …

… residues in the archaeal Sir2 from Archaeoglobus fulgidus increases the affinity of this … , the
rules that govern the substrate specificity of sirtuins have remained unclear, due in part to the …

… In order to aid in understanding the catalytic mechanism, substrate specificity, and inhibitory
mechanism of the sirtuin protein family, the three-dimensional structures of several sirtuin …

… human sirtuins, combined with synthesis … the distinct roles of individual sirtuins in living
organisms. This article is an effort to review progress made in the last 10 years to identify sirtuin …

… the importance of histones as sirtuin targets. In this review, we summarize our knowledge
regarding the range of sirtuin targets described to date and discuss the … , substrate specificity, …

… toward developing specific sirtuin modulators. This review summarizes the protein acylation/…
be involved in the sirtuin’s substrate specificity. Additionally, it has also been observed that …

… sirtuins, discussing the data that support the use of sirtuin-based therapies. Almost all … -specific
localization of the different sirtuins as well as some of their different substrate specificities, …

… specificity in binding of the peptide substrate within the enzyme cleft, detailed studies of the
substrate specificity of other sirtuins … This specificity may arise, in part, from residues on the …