The therapeutic potential of γ-Al2O3 nanoparticle containing 5-fluorouracil in the treatment of colorectal cancer

K Fasihi, F Amerizadeh, R Sabbaghzadeh, M Heydari… - Tissue and Cell, 2022 - Elsevier
Fluorouracil (5-FU) is being used in the treatment of several malignancies, but side effects
are often reported and include: diarrhea, vomiting, nausea, poor appetite, watery eyes, and
photophobia. We have developed and tested the cytotoxic activity of nanocrystalline powder
of γ-alumina (γ-Al 2 O 3) containing 5-FU in two-dimensional and three-dimensional (3D)
CRC cell culture. γ-Al 2 O 3 was prepared using a facile sol–gel method. The
physicochemical properties of nanoparticles were investigated by Fourier Transform Infrared …
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