Therapeutic angiogenesis in coronary artery disease: a review of mechanisms and current approaches
B Narasimhan, H Narasimhan… - Expert Opinion on …, 2021 - Taylor & Francis
Expert Opinion on Investigational Drugs, 2021•Taylor & Francis
Introduction Despite tremendous advances, the shortcomings of current therapies for
coronary disease are evidenced by the fact that it remains the leading cause of death in
many parts of the world. There is hence a drive to develop novel therapies to tackle this
disease. Therapeutic approaches to coronary angiogenesis have long been an area of
interest in lieu of its incredible, albeit unrealized potential. Areas covered This paper offers
an overview of mechanisms of native angiogenesis and a description of angiogenic growth …
coronary disease are evidenced by the fact that it remains the leading cause of death in
many parts of the world. There is hence a drive to develop novel therapies to tackle this
disease. Therapeutic approaches to coronary angiogenesis have long been an area of
interest in lieu of its incredible, albeit unrealized potential. Areas covered This paper offers
an overview of mechanisms of native angiogenesis and a description of angiogenic growth …
Introduction
Despite tremendous advances, the shortcomings of current therapies for coronary disease are evidenced by the fact that it remains the leading cause of death in many parts of the world. There is hence a drive to develop novel therapies to tackle this disease. Therapeutic approaches to coronary angiogenesis have long been an area of interest in lieu of its incredible, albeit unrealized potential.
Areas covered
This paper offers an overview of mechanisms of native angiogenesis and a description of angiogenic growth factors. It progresses to outline the advances in gene and stem cell therapy and provides a brief description of other investigational approaches to promote angiogenesis. Finally, the hurdles and limitations unique to this particular area of study are discussed.
Expert opinion
An effective, sustained, and safe therapeutic option for angiogenesis truly could be the paradigm shift for cardiovascular medicine. Unfortunately, clinically meaningful therapeutic options remain elusive because promising animal studies have not been replicated in human trials. The sheer complexity of this process means that numerous major hurdles remain before therapeutic angiogenesis truly makes its way from the bench to the bedside.
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