Thermodynamic signature of DNA damage: Characterization of DNA with a 5-hydroxy-2′-deoxycytidine· 2′-deoxyguanosine base pair
Oxidation of DNA due to exposure to reactive oxygen species is a major source of DNA
damage. One of the oxidation lesions formed, 5-hydroxy-2′-deoxycytidine, has been
shown to miscode by some replicative DNA polymerases but not by error prone
polymerases capable of translesion synthesis. The 5-hydroxy-2′-deoxycytidine lesion is
repaired by DNA glycosylases that require the 5-hydroxycytidine base to be extrahelical so it
can enter into the enzyme's active site where it is excised off the DNA backbone to afford an …
damage. One of the oxidation lesions formed, 5-hydroxy-2′-deoxycytidine, has been
shown to miscode by some replicative DNA polymerases but not by error prone
polymerases capable of translesion synthesis. The 5-hydroxy-2′-deoxycytidine lesion is
repaired by DNA glycosylases that require the 5-hydroxycytidine base to be extrahelical so it
can enter into the enzyme's active site where it is excised off the DNA backbone to afford an …
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