Antipsychotic drugs are prescribed to a wide range of individuals to treat mental health
conditions including schizophrenia. However, antipsychotic drugs cause bone loss and
increase fracture risk. We previously found that the atypical antipsychotic (AA) drug
risperidone causes bone loss through multiple pharmacological mechanisms, including
activation of the sympathetic nervous system in mice treated with clinically relevant doses.
However, bone loss was dependent upon housing temperature, which modulates …