Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia
N Oku, K Nagai, N Shindoh, Y Terada… - Bioorganic & medicinal …, 2004 - Elsevier
Bioorganic & medicinal chemistry letters, 2004•Elsevier
Three new cyclostellettamines, cyclostellettamine G (1), dehydrocyclostellettamines D (2),
and E (3), were isolated together with the known cyclostellettamine A (4) from a marine
sponge of the genus Xestospongia as histone deacetylase inhibitors. Their structures were
determined by spectral and chemical methods. They inhibit histone deacetylase derived
from K562 human leukemia cells with IC50 values ranging from 17 to 80μM.
and E (3), were isolated together with the known cyclostellettamine A (4) from a marine
sponge of the genus Xestospongia as histone deacetylase inhibitors. Their structures were
determined by spectral and chemical methods. They inhibit histone deacetylase derived
from K562 human leukemia cells with IC50 values ranging from 17 to 80μM.
Three new cyclostellettamines, cyclostellettamine G (1), dehydrocyclostellettamines D (2), and E (3), were isolated together with the known cyclostellettamine A (4) from a marine sponge of the genus Xestospongia as histone deacetylase inhibitors. Their structures were determined by spectral and chemical methods. They inhibit histone deacetylase derived from K562 human leukemia cells with IC50 values ranging from 17 to 80μM.
Elsevier
以上显示的是最相近的搜索结果。 查看全部搜索结果