… dependency on the simultaneous presence of Na+, K', and C1… time-dependent regulation
of Na'/K'/Cl- cotransport in glomerular mesangial cells. Second messenger analogues induced …

… Finally, we determined multiple ways to reduce the impact of the agent/probe interaction
on data acquisition. The addition of either fetal bovine serum (10%) or albumin (5%) to the …

… quinidine has greater affinity for one of two open states of the … on time-dependent outward
current reflects block of multiple … -induced delay in the activation of time-dependent outward …

… Both drug concentration and increasingly negative membrane potential augmented this
time-dependent effect. At negative membrane potentials piperocaine also reversibly accelerated …

… of the CYPs investigated were studied in incubations performed simultaneously on 96-well …
In the present study, none of the glucuronides caused time-dependent inhibition of CYP2C8. …

… CYP inhibition is classified into direct inhibition (DI) and time-dependent inhibition (TDI). DI
occurs when the parent compound itself reversibly inhibit CYP activity, while TDI is caused by …

… It successfully captured the main PK characteristics of the drug in adults but overpredicted
exposure to PMs after multiple doses. Therefore, the objectives of the present study were to 1) …

… induction and competitive and time-dependent inhibition of CYP3A4 and competitive
inhibition of … clearance in the presence of simultaneous competitive inhibition, time-dependent …

… ) concentration- and time-dependent inhibition of endothelium-… , followed by an appropriate
multiple range test that compared … ANOVA, followed by an appropriate multiple range test. All …

… ), which potentially transdifferentiate into multiple cell types, are … (D) Plots show time dependent
effects of adding MSCs or … Because pharmacologic inhibition might induce nonspecific …