[HTML][HTML] Tiny but mighty: use of next generation sequencing on discarded cytocentrifuged bile duct brushing specimens to increase sensitivity of cytological diagnosis
Bile duct brushing (BDB) is used to evaluate pancreatobiliary lesions as it widely samples
lesions with a low complication rate. Cytological evaluation of BDB is a specific but
insensitive test. There is limited literature on the use of post-cytocentrifuged (PCC) samples,
which are usually discarded, for next-generation sequencing (NGS) as an adjunct to
cytological diagnosis of BDB. In this study we investigate whether molecular analysis by
NGS of PCC specimens improves the sensitivity of diagnosis. PCC samples from 100 …
lesions with a low complication rate. Cytological evaluation of BDB is a specific but
insensitive test. There is limited literature on the use of post-cytocentrifuged (PCC) samples,
which are usually discarded, for next-generation sequencing (NGS) as an adjunct to
cytological diagnosis of BDB. In this study we investigate whether molecular analysis by
NGS of PCC specimens improves the sensitivity of diagnosis. PCC samples from 100 …