Human plasmacytoid dendritic cells (DC)(PDC, CD123+) and myeloid DC (MDC, CD11c+)
may be able to discriminate between distinct classes of microbial molecules based on a
different pattern of Toll‐like receptor (TLR) expression. TLR1–TLR9 were examined in
purified PDC and MDC. TLR9, which is critically involved in the recognition of CpG motifs in
mice, was present in PDCbut not in MDC. TLR4, which is required for the response to LPS,
was selectively expressed on MDC. Consistent with TLR expression, PDC were susceptible …

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for
plasmacytoid dendritic cells which synergizes with CD40L to induce high amounts of IL-12 …
TOLL-LIKE RECEPTOR EXPRESSION REVEALS CPG DNA AS A UNIQUE MICROBIAL
STIMULUS FOR PLASMACYTOID DENDRITIC CELLS WHICH SYNERGIZES WITH CD40L
TO INDUCE HIGH AMOUNTS OF IL-12 …