Toll-like receptor 4 polymorphisms and atherogenesis

S Kiechl, E Lorenz, M Reindl… - … England Journal of …, 2002 - Mass Medical Soc
Background The ability to mount a prominent inflammatory response to bacterial pathogens
confers an advantage in innate immune defense but may signal an increased risk of
atherosclerosis. We determined whether recently discovered genetic variants of toll-like
receptor 4 (TLR4) that confer differences in the inflammatory response elicited by bacterial
lipopolysaccharide are related to the development of atherosclerosis. Methods As part of the
five-year follow-up in the Bruneck (Italy) Study, we screened 810 persons in the study cohort …

[引用][C] Toll-like receptor 4 polymorphisms and atherogenesis.

B Beutler, E Beutler - The New England journal of medicine, 2002 - europepmc.org
Toll-like receptor 4 polymorphisms and atherogenesis. - Abstract - Europe PMC … Toll-like
receptor 4 polymorphisms and atherogenesis. … This is a comment on "Toll-like receptor 4
polymorphisms and atherogenesis." N Engl J Med. 2002 Jul 18;347(3):185-92. …
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