Background: Cardiac ischemic injury induces a pathological remodeling response, which
can ultimately lead to heart failure. Detailed mechanistic insights into molecular signaling
pathways relevant for different aspects of cardiac remodeling will support the identification of
novel therapeutic targets. Methods: Although genome-wide transcriptome analysis on
diseased tissues has greatly advanced our understanding of the regulatory networks that
drive pathological changes in the heart, this approach has been disadvantaged by the fact …

Background—Cardiac ischemic injury induces a pathological remodeling response, which
can ultimately lead to heart failure. Detailed mechanistic insights into molecular signaling
pathways relevant for different aspects of cardiac remodeling will support the identification of
novel therapeutic targets. Methods—While genome-wide transcriptome analysis on
diseased tissues has greatly advanced our understanding of the regulatory networks that
drive pathological changes in the heart, this approach has been disadvantaged by the fact …