Topical delivery of Mannose Conjugated-Doxorubicin-Berberine nanostructured lipid carrier gel for skin cancer amelioration: formulation optimization, in-silico, in-vitro …
Mannose-conjugated doxorubicin (DOX) and berberine (BBR) loaded nanostructured lipid
carriers (Ma-DB-NLC) topical gel was formulated for skin cancer treatment. DOX is a potent
anticancer drug that was combined with BBR to synergize the clinical efficacy of the
formulation in skin cancer treatment. The findings of the in-silico study indicated that DOX &
BBR were the promising ligands of DNA-Topoisomerase-Ⅱ & p13k, with excellent docking
scores. The central composite rotatable design (CCRD) was used to optimize the NLC …
carriers (Ma-DB-NLC) topical gel was formulated for skin cancer treatment. DOX is a potent
anticancer drug that was combined with BBR to synergize the clinical efficacy of the
formulation in skin cancer treatment. The findings of the in-silico study indicated that DOX &
BBR were the promising ligands of DNA-Topoisomerase-Ⅱ & p13k, with excellent docking
scores. The central composite rotatable design (CCRD) was used to optimize the NLC …