Total Synthesis of (+)‐Petromyroxol, a Marine Natural Product
Asian Journal of Organic Chemistry, 2015•Wiley Online Library
… Herein, we report a synthetic approach for the total synthesis of (+)-petromyroxol
employing Sharpless asymmetric dihydroxylation (AD), intramolecular S N 2 cyclization,
and stereoselective Grignard reaction as the key steps. Our synthetic approach for the
synthesis of (+)-petromyroxol was envisioned via the retrosynthetic route as shown in
Scheme 1. The 2,5-disubstituted-3-oxygenated THF derivative 6 was visualized as a
synthetic intermediate from which (+)-… In conclusion, an efficient approach to the total …
employing Sharpless asymmetric dihydroxylation (AD), intramolecular S N 2 cyclization,
and stereoselective Grignard reaction as the key steps. Our synthetic approach for the
synthesis of (+)-petromyroxol was envisioned via the retrosynthetic route as shown in
Scheme 1. The 2,5-disubstituted-3-oxygenated THF derivative 6 was visualized as a
synthetic intermediate from which (+)-… In conclusion, an efficient approach to the total …
Abstract
An efficient total synthesis of (+)‐petromyroxol, a marine natural product, is described. The synthesis utilizes the Sharpless asymmetric dihydroxylation (AD), intramolecular SN2 cyclization and stereoselective Grignard reaction as key steps.
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