Toward an understanding of the retinal chromophore in rhodopsin mimics
Recently, a rhodopsin protein mimic was constructed by combining mutants of the cellular
retinoic acid binding protein II (CRABPII) with an all-trans retinal chromophore. Here, we
present a combined computational quantum mechanics/molecular mechanics (QM/MM) and
experimental ultrafast kinetic study of CRABPII. We employ the QM/MM models to study the
absorption (λamax), fluorescence (λfmax), and reactivity of a CRABPII triple mutant
incorporating the all-trans protonated chromophore (PSB-KLE-CRABPII). We also study the …
retinoic acid binding protein II (CRABPII) with an all-trans retinal chromophore. Here, we
present a combined computational quantum mechanics/molecular mechanics (QM/MM) and
experimental ultrafast kinetic study of CRABPII. We employ the QM/MM models to study the
absorption (λamax), fluorescence (λfmax), and reactivity of a CRABPII triple mutant
incorporating the all-trans protonated chromophore (PSB-KLE-CRABPII). We also study the …
[引用][C] Toward an Understanding of the Retinal Chromophore in Rhodopsin Mimics
G Samer, V Chrysoula, V Mikas, B Babak, S Igor… - 2013
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