The liquefied natural gas (LNG) chain requires significant amounts of resources. Enhancing its efficiency is essential due to environmental concerns, amongst others. Here, we presented various optimization, integration, and multi-scale opportunities that can improve the chain's outputs for a given feed. Our recommendations were derived from rigorous thermodynamic analyses while considering multiple operational modes. Many opportunities were identified; some are suitable for immediate implementation, while others are futuristic. The most appealing options relate to the deployment of cutting-edge energy generators. For 7.81GW feed exergy, the chain's prevailing holding mode loss is enough to power a mega LNG plant processing 23GW feed exergy. Many heat integration opportunities are missed due to standard practices. Losses in standalone mode can be misleading. When considering the utility steps, liquefaction and sweetening losses are the highest. Fuel cells and solar energy are well suited for these and can potentially enhance the chain LNG delivery by over 30%.