Trace class operators for quaternionic Hilbert spaces (QHS) were studied by Moretti and Oppio [18]. In this paper, we study trace class operators via operator valued frames (OPV-frames). We introduce OPV-frames in a right quaternionic Hilbert space H with range in a two sided quaternionic Hilbert space K and obtain various results including several characterizations of OPV-frames. Also, we obtain a necessary and sufficient condition for a bounded operator on a right QHS to be a trace class operator which generalizes a similar result by Attal [2]. Moreover, we construct a trace class operator on a two sided QHS. Finally, we study quaternionic quantum channels as completely positive trace preserving maps and obtain various Choi-Kraus type representations of quaternionic quantum channels using OPV-frames in quaternionic Hilbert spaces.