[HTML][HTML] Trace elements during primordial plexiform network formation in human cerebral organoids

RC Sartore, SC Cardoso, YVM Lages, JM Paraguassu… - PeerJ, 2017 - peerj.com
Systematic studies of micronutrients during brain formation are hindered by restrictions to
animal models and adult post-mortem tissues. Recently, advances in stem cell biology have
enabled recapitulation of the early stages of human telencephalon development in vitro. In
the present work, we analyzed cerebral organoids derived from human pluripotent stem
cells by synchrotron radiation X-ray fluorescence in order to measure biologically valuable
micronutrients incorporated and distributed into the exogenously developing brain. Our …

[PDF][PDF] Trace elements during primordial plexiform network

RF Stelling, MZP Guimarães, CA Pérez, K Stevens - pdfs.semanticscholar.org
Abstract 31 Systematic studies of micronutrients during brain formation are hindered by
restrictions to 32 animal models and adult post-mortem tissues. Recently, advances in stem
cell biology have 33 enabled recapitulation of the early stages of human telencephalon
development in vitro. In the 34 present work, we analyzed cerebral organoids derived from
human pluripotent stem cells by 35 synchrotron radiation X-ray fluorescence in order to
measure biologically valuable 36 micronutrients incorporated and distributed into the …
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