Tracking of multimodal therapeutic nanocomplexes targeting breast cancer in vivo

R Bardhan, W Chen, M Bartels, C Perez-Torres… - Nano …, 2010 - ACS Publications
R Bardhan, W Chen, M Bartels, C Perez-Torres, MF Botero, RW McAninch, A Contreras…
Nano letters, 2010ACS Publications
Nanoparticle-based therapeutics with local delivery and external electromagnetic field
modulation holds extraordinary promise for soft-tissue cancers such as breast cancer;
however, knowledge of the distribution and fate of nanoparticles in vivo is crucial for clinical
translation. Here we demonstrate that multiple diagnostic capabilities can be introduced in
photothermal therapeutic nanocomplexes by simultaneously enhancing both near-infrared
fluorescence and magnetic resonance imaging (MRI). We track nanocomplexes in vivo …
Nanoparticle-based therapeutics with local delivery and external electromagnetic field modulation holds extraordinary promise for soft-tissue cancers such as breast cancer; however, knowledge of the distribution and fate of nanoparticles in vivo is crucial for clinical translation. Here we demonstrate that multiple diagnostic capabilities can be introduced in photothermal therapeutic nanocomplexes by simultaneously enhancing both near-infrared fluorescence and magnetic resonance imaging (MRI). We track nanocomplexes in vivo, examining the influence of HER2 antibody targeting on nanocomplex distribution over 72 h. This approach provides valuable, detailed information regarding the distribution and fate of complex nanoparticles designed for specific diagnostic and therapeutic functions.
ACS Publications
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