Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse …
JR McLean, PJ Hallett, O Cooper, M Stanley… - Molecular and Cellular …, 2012 - Elsevier
Alternative splicing is a complex post-transcriptional process that can be regulated by cis-
acting elements located within genomic non-coding regions. Recent studies have identified
that polymorphic variations in non-coding regions of the α-synuclein gene (SNCA) locus are
associated with an increased risk for developing Parkinson's disease (PD). The underlying
mechanism (s) for this susceptibility may involve changes in α-synuclein mRNA expression
and alternative splicing. As a first step towards understanding the biology of α-synuclein …
acting elements located within genomic non-coding regions. Recent studies have identified
that polymorphic variations in non-coding regions of the α-synuclein gene (SNCA) locus are
associated with an increased risk for developing Parkinson's disease (PD). The underlying
mechanism (s) for this susceptibility may involve changes in α-synuclein mRNA expression
and alternative splicing. As a first step towards understanding the biology of α-synuclein …