Dental follicle is a loose connective tissue that surrounds the developing tooth. Dental
follicle cells (DFCs) have a promising potential for tissue engineering applications including
periodontal and bone regeneration. However, little is known about the molecular
mechanisms underlying osteogenic differentiation. In a previous study we detected that
more than 35% of genes that are regulated during osteogenic differentiation of DFCs have
promoter binding sites for the transcription factors TP53 and SP1. However, the role of these …