Transcription-based circadian mechanism controls the duration of molecular clock states in response to signaling inputs
S Almeida, M Chaves, F Delaunay - Journal of theoretical biology, 2020 - Elsevier
The molecular oscillator of the mammalian circadian clock consists in a dynamical network
of genes and proteins whose main regulatory mechanisms occur at the transcriptional level.
From a dynamical point of view, the mechanisms leading to an oscillatory solution with an
orderly protein peak expression and a clear day/night phase distinction remain unclear. Our
goal is to identify the essential interactions needed to generate phase opposition between
the activating CLOCK: BMAL1 and the repressing PER: CRY complexes and to better …
of genes and proteins whose main regulatory mechanisms occur at the transcriptional level.
From a dynamical point of view, the mechanisms leading to an oscillatory solution with an
orderly protein peak expression and a clear day/night phase distinction remain unclear. Our
goal is to identify the essential interactions needed to generate phase opposition between
the activating CLOCK: BMAL1 and the repressing PER: CRY complexes and to better …
Transcription-based circadian mechanism controls the duration of molecular clock states in response to signaling inputs
M Chaves, F Delaunay - 2020 - agris.fao.org
The molecular oscillator of the mammalian circadian clock consists in a dynamical network
of genes and proteins whose main regulatory mechanisms occur at the transcriptional level.
From a dynamical point of view, the mechanisms leading to an oscillatory solution with an
orderly protein peak expression and a clear day/night phase distinction remain unclear. Our
goal is to identify the essential interactions needed to generate phase opposition between
the activating CLOCK: BMAL1 and the repressing PER: CRY complexes and to better …
of genes and proteins whose main regulatory mechanisms occur at the transcriptional level.
From a dynamical point of view, the mechanisms leading to an oscillatory solution with an
orderly protein peak expression and a clear day/night phase distinction remain unclear. Our
goal is to identify the essential interactions needed to generate phase opposition between
the activating CLOCK: BMAL1 and the repressing PER: CRY complexes and to better …
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