Transcriptional analysis of acetylcholine receptor α3 gene promoter motifs that bind Sp1 and AP2
X Yang, D Fyodorov, ES Deneris - Journal of Biological Chemistry, 1995 - ASBMB
In this study, we performed an analysis of the neuronal nicotinic acetylcholine receptor α3
subunit gene promoter region,− 238/+ 47, to identify cis and trans elements that are
important for basal activity in PC12 cells. Sequence analyses of the α3 promoter and
footprint assays revealed an Sp1 binding site between− 79 and− 57 (termed the α3 GA
motif) and an AP2 binding site between− 30 and− 7. Using mobility shift analysis, we found
that PC12 cell extracts contain proteins that specifically bind to the α3 GA motif and are …
subunit gene promoter region,− 238/+ 47, to identify cis and trans elements that are
important for basal activity in PC12 cells. Sequence analyses of the α3 promoter and
footprint assays revealed an Sp1 binding site between− 79 and− 57 (termed the α3 GA
motif) and an AP2 binding site between− 30 and− 7. Using mobility shift analysis, we found
that PC12 cell extracts contain proteins that specifically bind to the α3 GA motif and are …
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