Transcriptional and functional profiling identifies inflammation and endothelial-to-mesenchymal transition as potential drivers for phenotypic heterogeneity within a …
SNJ Laan, S de Boer, RJ Dirven, I van Moort… - Journal of Thrombosis …, 2024 - Elsevier
Background Endothelial colony-forming cells (ECFCs) derived from patients can be used to
investigate pathogenic mechanisms of vascular diseases like von Willebrand disease.
Considerable phenotypic heterogeneity has been observed between ECFC clones derived
from healthy donors. This heterogeneity needs to be well understood in order to use ECFCs
as endothelial models for disease. Objectives Therefore, we aimed to determine phenotypic
and gene expression differences between control ECFCs. Methods A total of 34 ECFC …
investigate pathogenic mechanisms of vascular diseases like von Willebrand disease.
Considerable phenotypic heterogeneity has been observed between ECFC clones derived
from healthy donors. This heterogeneity needs to be well understood in order to use ECFCs
as endothelial models for disease. Objectives Therefore, we aimed to determine phenotypic
and gene expression differences between control ECFCs. Methods A total of 34 ECFC …
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