Transcriptome analysis of developing lens reveals abundance of novel transcripts and extensive splicing alterations
Lens development involves a complex and highly orchestrated regulatory program. Here,
we investigate the transcriptomic alterations and splicing events during mouse lens
formation using RNA-seq data from multiple developmental stages, and construct a
molecular portrait of known and novel transcripts. We show that the extent of novelty of
expressed transcripts decreases significantly in post-natal lens compared to embryonic
stages. Characterization of novel transcripts into partially novel transcripts (PNTs) and …
we investigate the transcriptomic alterations and splicing events during mouse lens
formation using RNA-seq data from multiple developmental stages, and construct a
molecular portrait of known and novel transcripts. We show that the extent of novelty of
expressed transcripts decreases significantly in post-natal lens compared to embryonic
stages. Characterization of novel transcripts into partially novel transcripts (PNTs) and …
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