Transglutaminase 2 is expressed and active on the surface of human monocyte-derived dendritic cells and macrophages
The multifunctional enzyme, transglutaminase 2 (TG2), can be found intracellularly, in the
extracellular matrix and on the cell surface. Cell surface TG2 (csTG2) could not be detected
by TG2-specific antibodies or autoantibodies on immunocompetent cells. A supposedly
csTG2-specific antibody, 6B9, was recently shown to actually react with CD44. Though the
importance of TG2-mediated deamidation of gluten in the pathogenesis of celiac disease
has been well recognized, it is not known in which intestinal cells or cell compartment the …
extracellular matrix and on the cell surface. Cell surface TG2 (csTG2) could not be detected
by TG2-specific antibodies or autoantibodies on immunocompetent cells. A supposedly
csTG2-specific antibody, 6B9, was recently shown to actually react with CD44. Though the
importance of TG2-mediated deamidation of gluten in the pathogenesis of celiac disease
has been well recognized, it is not known in which intestinal cells or cell compartment the …
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