In the Wood–Ljungdahl carbon fixation pathway, protein–protein interactions between
methyltransferase (MeTr) and corrinoid iron–sulfur protein (CFeSP) are required for the
transfer of a methyl group. While crystal structures have been determined for MeTr and
CFeSP both free and in complex, solution structures have not been established. Here, we
examine the transient interactions between MeTr and CFeSP in solution using anaerobic
small-angle X-ray scattering (SAXS) and present a global analysis approach for the …