Transient global ischemia in rat brain promotes different NMDA receptor regulation depending on the brain structure studied
S Dos-Anjos, B Martínez-Villayandre, S Montori… - Neurochemistry …, 2009 - Elsevier
The mRNA expression of the major subunits of N-methyl-d-aspartate receptors (NR1, NR2A
and NR2B) following ischemia–reperfusion was studied in structures with different
vulnerabilities to ischemic insult in the rat brain. The study was performed using quantitative
real-time PCR on samples from 3-month-old male Sprague–Dawley rats after global
transient forebrain ischemia followed by 48h of reperfusion. Expression of NMDA receptor
subunits mRNAs decreased significantly in all structures studied in the injured animals as …
and NR2B) following ischemia–reperfusion was studied in structures with different
vulnerabilities to ischemic insult in the rat brain. The study was performed using quantitative
real-time PCR on samples from 3-month-old male Sprague–Dawley rats after global
transient forebrain ischemia followed by 48h of reperfusion. Expression of NMDA receptor
subunits mRNAs decreased significantly in all structures studied in the injured animals as …
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