[HTML][HTML] Treatment of Helicobacter pylori infection in children: A systematic review
FAF da Silva, BB de Brito, MLC Santos… - World Journal of Meta …, 2020 - wjgnet.com
FAF da Silva, BB de Brito, MLC Santos, HS Marques, MM Sampaio, RT da Silva Júnior…
World Journal of Meta-Analysis, 2020•wjgnet.comBACKGROUND Helicobacter pylori (H. pylori) infection is predominantly acquired in
childhood. When indicated, the most accepted treatment for H. pylori eradication in this age
group is first-line triple therapy. However, the increasing resistance to clarithromycin and
nitroimidazoles has been associated with treatment failure, and thus, alternative treatment
regimens have been proposed. AIM To perform a systematic review of randomized
controlled trials on treatment regimens for H. pylori infection in children. METHODS We …
childhood. When indicated, the most accepted treatment for H. pylori eradication in this age
group is first-line triple therapy. However, the increasing resistance to clarithromycin and
nitroimidazoles has been associated with treatment failure, and thus, alternative treatment
regimens have been proposed. AIM To perform a systematic review of randomized
controlled trials on treatment regimens for H. pylori infection in children. METHODS We …
Abstract
BACKGROUND
Helicobacter pylori (H. pylori) infection is predominantly acquired in childhood. When indicated, the most accepted treatment for H. pylori eradication in this age group is first-line triple therapy. However, the increasing resistance to clarithromycin and nitroimidazoles has been associated with treatment failure, and thus, alternative treatment regimens have been proposed.
AIM
To perform a systematic review of randomized controlled trials on treatment regimens for H. pylori infection in children.
METHODS
We surveyed relevant articles published in English from 2010 to April 2020 in the PubMed and MEDLINE databases. Keywords included “Helicobacter pylori”/” children or childhood”/” treatment or eradication.” The risk of bias was evaluated according to the Cochrane Handbook of Systematic Reviews for Interventions.
RESULTS
Among the 1144 records identified through the database, 20 articles were selected. Four studies compared the eradication rates of H. pylori infection between standard triple therapies, changing only the main antibiotic used. Seven studies evaluated the effectiveness of standard triple therapy with the addition of probiotics. One study investigated the relationship between the effectiveness in the eradication rates of standard triple therapy and vitamin E levels. Six studies analyzed the eradication rates of sequential therapy.
CONCLUSION
The findings suggest that although standard triple therapy is the most recommended regimen for children by the current guidelines, other therapeutic schemes have shown promising results and may also be recommended for clinical practice in the future.
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