Treatment of biofilm infections on implants with low-frequency ultrasound and antibiotics
JC Carmen, BL Roeder, JL Nelson, RLR Ogilvie… - American journal of …, 2005 - Elsevier
Medical implants are sometimes colonized by biofilm-forming bacteria, which are very
difficult to treat effectively. The combination of gentamicin and ultrasonic exposure for 24
hours was previously shown to reduce the viability of Escherichia coli biofilms in vivo. This
article shows that such treatment for 48 hours reduced viable E coli bacteria to nearly
undetectable levels. However, when Pseudomonas aeruginosa biofilms were implanted and
treated for 24 and 48 hours, no significant ultrasonic-enhanced reduction of viable bacteria …
difficult to treat effectively. The combination of gentamicin and ultrasonic exposure for 24
hours was previously shown to reduce the viability of Escherichia coli biofilms in vivo. This
article shows that such treatment for 48 hours reduced viable E coli bacteria to nearly
undetectable levels. However, when Pseudomonas aeruginosa biofilms were implanted and
treated for 24 and 48 hours, no significant ultrasonic-enhanced reduction of viable bacteria …