Human monocyte-derived dendritic cells (DCs) show remarkable phenotypic changes upon
direct contact with soluble products (SPs) of Trichuris suis, a pig whipworm that is
experimentally used in therapies to ameliorate inflammation in patients with Crohn's disease
and multiple sclerosis. These changes may contribute to the observed induction of a T
helper 2 (Th2) response and the suppression of Toll-like receptor (TLR)-induced Th1 and
Th17 responses by human DCs primed with T. suis SPs. Here it is demonstrated that …