Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution
DJ Callahan, W Liu, X Li, MR Dreher, W Hassouneh… - Nano …, 2012 - ACS Publications
Nano letters, 2012•ACS Publications
To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report
the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of
solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at
37° C into spherical micelles that are stabilized by Zn2+ and are disrupted as the pH drops
from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and
distribution in tumors than a pH-insensitive control.
the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of
solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at
37° C into spherical micelles that are stabilized by Zn2+ and are disrupted as the pH drops
from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and
distribution in tumors than a pH-insensitive control.
To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn2+ and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.
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