Triplex tetra-primer ARMS-PCR method for the simultaneous detection of MTHFR c. 677C> T and c. 1298A> C, and MTRR c. 66A> G polymorphisms of the folate …
The folate-homocysteine metabolic pathway was shown to play an important role in several
diseases such as cancers, cardiovascular diseases, and neurodegenerative diseases. The
c. 677C> T and c. 1298A> C polymorphisms of the Methylenetetrahydrofolate reductase
(MTHFR) gene, and c. 66A> G of the Methionine synthase reductase (MTRR) gene are the
most commonly investigated polymorphisms in the folate-homocysteine metabolic pathway.
The currently used methods for the detection of the three polymorphisms are either slow and …
diseases such as cancers, cardiovascular diseases, and neurodegenerative diseases. The
c. 677C> T and c. 1298A> C polymorphisms of the Methylenetetrahydrofolate reductase
(MTHFR) gene, and c. 66A> G of the Methionine synthase reductase (MTRR) gene are the
most commonly investigated polymorphisms in the folate-homocysteine metabolic pathway.
The currently used methods for the detection of the three polymorphisms are either slow and …
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