Tryptophan-2, 3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis
The catabolism of tryptophan to immunosuppressive and neuroactive kynurenines is a key
metabolic pathway regulating immune responses and neurotoxicity. The rate-limiting step is
controlled by indoleamine-2, 3-dioxygenase (IDO) and tryptophan-2, 3-dioxygenase (TDO).
IDO is expressed in antigen presenting cells during immune reactions, hepatic TDO
regulates blood homeostasis of tryptophan and neuronal TDO influences neurogenesis.
While the role of IDO has been described in multiple immunological settings, little is known …
metabolic pathway regulating immune responses and neurotoxicity. The rate-limiting step is
controlled by indoleamine-2, 3-dioxygenase (IDO) and tryptophan-2, 3-dioxygenase (TDO).
IDO is expressed in antigen presenting cells during immune reactions, hepatic TDO
regulates blood homeostasis of tryptophan and neuronal TDO influences neurogenesis.
While the role of IDO has been described in multiple immunological settings, little is known …
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